منابع مشابه
Cytochrome P450: taming a wild type enzyme.
Protein engineering of cytochrome P450 monooxygenases (P450s) has been very successful in generating valuable non-natural activities and properties, allowing these powerful catalysts to be used for the synthesis of drug metabolites and in biosynthetic pathways for the production of precursors of artemisinin and paclitaxel. Collected experience indicates that the P450s are highly 'evolvable' - t...
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Cytochrome P450 (CYP) is a heme containing enzyme superfamily that catalyzes the oxidative biotransformation of lipophilic substrates to hydrophilic metabolites facilitating their removal from cells. The CYPs were first recognized by Martin Klingenberg (Klingenberg, 1958) while studying the spectrophotometric properties of pigments in a microsomal fraction prepared from rat livers. When a dilut...
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In this paper the suitability of different document representations for automatic document classification is compared, investigating a whole range of representations between bag-of-words and bag-of-phrases. We look at some of their statistical properties, and determine for each representation the optimal choice of classification parameters and the effect of Term Selection. Phrases are represent...
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We are investigating the redox chemistry of wild-type (WT) and mutant (1-12G) cytochrome P450 BM3. Absorption spectra in solution feature the Fe(III) Soret at 418 nm for WT and a split Soret for 1-12G at 390 and 418 nm. Voltammetry of the proteins within DDAPSS films on the surface of carbon electrodes reveal nearly identical Fe(III/II) potentials (approximately -200 mV vs Ag/AgCl), but signifi...
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Wild Big Data (WBD) is data that is hard to extract, understand, and use due to its heterogeneous nature and volume. It typically comes without a schema, is obtained from multiple sources and provides a challenge for information extraction and integration. We describe a way to subduing WBD that uses techniques and resources that are popular for processing natural language text. The approach is ...
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ژورنال
عنوان ژورنال: Current Opinion in Biotechnology
سال: 2011
ISSN: 0958-1669
DOI: 10.1016/j.copbio.2011.02.008